Types of EB
There was a recent update of the classification system (2019). In simple terms, EB cases are grouped together by the genetic defect itself, which results in where precisely the blisters occur in the skin, and the resulting clinical behaviours. Severe cases will present as a blistered baby at birth, whilst milder cases may only reveal problems when the child crawls, walks or runs or even later as young adults become more active. Patients with the mildest form of the disease may never have to seek medical help.

Only read the following sections when your child has a definitive diagnosis, and only read the subsection relevant to you and your family.
Dystrophic EB (DEB) In DEB, the skin comes away deeper down inside the skin, which means that, in simple terms, more of the skin tissue comes away and is lost. As the cells that replenish the skin are more prone to damage, scarring ie ‘dystrophy’ is a characteristic of DEB. read more
EB simplex (EBS) EBS is the most common type of EB (70%). The skin comes loose nearer to the skin’s surface, thus, generally speaking, healing is better than DEB and JEB and scarring is less of a problem. It can be worse in hot humid weather, and in some cases hot food or drinks can causing blistering in the mouth. It is usually caused by mutations in the genes for keratin 5 or keratin 14, which are often inherited in a dominant manner. read more
Junctional EB (JEB) JEB is the least common form of EB, constituting about 10% of all cases and is inherited in a recessive manner. read more
Kindler syndrome This is often considered to be a ‘mixed’ form because blisters can form at any level. read more
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