Itching is a common but complex problem. It leads to scratching that releases chemicals such as histamine in the skin that further increases inflammation, and intensifies the itch. And so on.

A myriad of factors may be implicated and though management is best aimed at eliminating the underlying cause, but this usually isn’t possible. It will be partly due to dry skin, inflammation and persistent skin damage with constant wound healing. Itch is a particular problem in EBS-DM.